United States, Minnesota, Big Stone, Big Stone National Wildlife Refuge. Big Stone County ... Ca. 2 mi. SE of Ortonville on Rte. 75; Big Stone Wildlife Refuge ... ca. 0.6 mi. SSE of main entrance, E of road. E1/2 SE1/4 NE1/4 Sec. 27 T121N R46W (Ortonville 27). 121N 46W 27